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Three dimensional tissue construction by cell assembly
Reference
TF416991
Principal Investigator / Supervisor
Professor Julian B Chaudhuri
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Chemical Engineering
Funding type
Research
Value (£)
372,796
Status
Completed
Type
Research Grant
Start date
01/02/2002
End date
01/02/2005
Duration
36 months
Abstract
Human tissue that is made in vitro for use in reconstruction of the body has been grown in a variety of scaffold materials. Two disadvantages with most scaffolds are 1). the tendency of the tissue to acquire a dense outer layer of extracellular matrix at the expense of the inner tissue mass and 2). the difficulty of delivering mixed cell populations in such a way that organised tissue will result. Organised, composite tissues will offer advantages in gaining good integration of host to graft. In addition, the aim of providing an array of channels as close as possible to a natural vascular system is an important one is the tissue implant is to survive and grow. This project addresses both of these challenges by developing a culture method based upon an expandable scaffold that will provide the means for controlling tissue density during culture and for introducing successive layers and/or cell subpopulations.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Foresight 4 (FS4) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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