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Engineered biological synthesis of drugs
Reference
TF08121
Principal Investigator / Supervisor
Professor Peter Leadlay
Co-Investigators /
Co-Supervisors
Professor James Staunton
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
992,188
Status
Completed
Type
Research Grant
Start date
01/09/1996
End date
30/09/2001
Duration
61 months
Abstract
We propose a wide-ranging and fundamental study of modular polyketide synthases, to establish generic technologies for: (1) rational engineering of known bioactive compounds to make hitherto inaccessible derivatives; and (2) development of an effective biological counterpart of combinatorial chemistry, to generate large numbers of diverse compounds as potential leads in drug discovery.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Technology Foresight 1 (TF1) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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