Award details

Replacement of organic solvents with compressed CO2 for the extraction of intercellular microbial metabolites

Reference	SPC04106
Principal Investigator / Supervisor	Dr A Biddlestone
Co-Investigators / Co-Supervisors	Dr M King, Professor Andrew Lyddiatt
Institution	University of Birmingham
Department	Chemical Engineering
Funding type	Research
Value (£)	186,886
Status	Completed
Type	Research Grant
Start date	01/01/1996
End date	01/01/1999
Duration	36 months

Abstract

The feasibility of (and mechanisms involved in) the extraction of hydrophobic material from aqueous slurries or pastes using compressed CO2 as solvent is to be investigated. A particular example selected is the extraction of rapamycin (a typical intracellular metabolite) from its parent cells which in turn will be present as an aqueous paste. The replacement of organic extractants by CO2 is considered and costed. Appropriate equilibrium and mass transfer rate determinations will be made and the effects of the extraction procedure on the viability and morphology of the cells studied. Visual observations of flow regime and slurry dispersal will be made in a windowed cell.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Separation Processes Committee (SPC) [1992-1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search