Award details

Chromatographic materials for the specific separation of oligonucleotides and nucleic acids

Reference	SPC04066
Principal Investigator / Supervisor	Professor David Barrett
Co-Investigators / Co-Supervisors	Professor Martyn Davies, Dr P Shaw
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	130,330
Status	Completed
Type	Research Grant
Start date	02/01/1996
End date	02/02/1999
Duration	37 months

Abstract

This collaborative project will examine a series of novel affinity ligands which will interact in a highly specific manner with oligonucleotides and related nucleic acid compounds. Their potential in the analytical and process scale purifications of nucleic acid-related compounds will be investigated using chromatographic, spectroscopic and surface analytical techniques. Special emphasis will be placed on understanding and controlling the specificity and kinetics of the molecular interaction with the target molecules. It is projected that the fundamental work in this proposal will lead to an improved understanding of biospecific separations of DNA, RNA and oligonucleotides, which will have direct practical relevance to the purification of these high-value pharmaceutical products.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Separation Processes Committee (SPC) [1992-1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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