Award details

Quantitative prediction of protein fractionation at synthetic membranes

Reference	SPC03901
Principal Investigator / Supervisor	Professor W Bowen
Co-Investigators / Co-Supervisors	Dr J Pitman
Institution	Swansea University
Department	Chemical & Biological Process Eng
Funding type	Research
Value (£)	144,300
Status	Completed
Type	Research Grant
Start date	01/10/1995
End date	01/02/1999
Duration	40 months

Abstract

There is substantial industrial interest in the fractionation of mixtures of proteins. Recent experimental work has shown that membrane processes may be used for such separations if the electrical interactions between proteins and membranes are controlled by careful selection of processing conditions, in particular, pH, ionic strength and operating pressure. The aim of the project is to facilitate the industrial implementation of such membrane fractionation by providing a rigorous, realistic and predictive mathematical description of the electrical and hydrodynamic forces experienced by a protein on approach to and when entering a membrane pore. London-van der Waals and hydration forces will also be included. Calculations will be carried out in three-dimensions using the finite element method, hence allowing calculation for real protein shape and charge distribution. Post-processing of such calculations will allow prediction for real membrane pore size distributions. The calculations will be validated experimentally.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Separation Processes Committee (SPC) [1992-1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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