Award details

BBSRC Professorial Fellowship Experimental analysis of ageing

Reference	SF19106
Principal Investigator / Supervisor	Professor Linda Partridge
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	361,984
Status	Completed
Type	Fellowships
Start date	01/08/2002
End date	01/08/2007
Duration	60 months

Abstract

The objective of this programme of research is to discover the mechanisms by which normal ageing occurs. Because mechanisms of ageing are conserved over large evolutionary distances, I shall mainly use a model organism, the fruit fly Drosophila. This will allow the research to proceed more rapidly than would otherwise be possible. Interventions that slow down ageing are particularly useful experimental investigations of its mechanisms. In contrast, interventions that lower survival or fecundity could merely introduce novel pathologies. The first specific objective of the work will be to discover how three key interventions, caloric restriction, reduced reproductive rate and reduced signalling through an insulin/IGF-like pathway slow down ageing. The second objective will be to understand what forms of damage are ameliorated by these interventions and, in particular, to test the hypothesis that they all reduce the impact of oxidative damage.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Fellowship - Professorial Fellowship (PF) [1996-2009]
Funding Scheme	X – not Funded via a specific Funding Scheme

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