Award details

BBSRC Senior Fellowship: a study of the homeobox genes and signalling pathway that regulate sexual development in the mushroom Coprinus

Reference	SF08155
Principal Investigator / Supervisor	Dr L Casselton
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	Plant Sciences
Funding type	Research
Value (£)	353,361
Status	Completed
Type	Fellowships
Start date	01/12/1996
End date	01/12/2001
Duration	60 months

Abstract

The mating type genes of the mushroom Coprinus cinereus map to two complex loci known as A and B. Compatible mates have different alleles of genes at both loci and mating triggers a developmental pathway that converts an asexual monokaryon with uninucleate cells and asexual spores (oidia) into a fertile dikaryon with binucleate cells and characteristic clamp connections between each cell. No special cells are involved in mating, fusion is between somatic cells and remarkably, recognition of whether this occurred between self or non-self cells is only sensed subsequently. My work with C. cinereus addresses the fundamental problem of how cells distinguish self from non-self and how this leads to regulated gene expression; it focuses on proteins and pathways that are highly conserved in all eukaryotic organisms.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Fellowship - Professorial Fellowship (PF) [1996-2009]
Funding Scheme	X – not Funded via a specific Funding Scheme

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