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Making of computer-based digital atlas of mouse development - Professor M H Kaufman

Reference	SCM00726
Principal Investigator / Supervisor	Professor Jonathan Bard
Co-Investigators / Co-Supervisors	Professor M Kaufman
Institution	University of Edinburgh
Department	Biomedical Sciences
Funding type	Research
Value (£)	182,979
Status	Completed
Type	Research Grant
Start date	01/09/1994
End date	01/09/1997
Duration	36 months

Abstract

The genetic analysis of embryonic development in mammals is generating a large and unwieldy resource of information on gene expression and mutant phenotype. We need a strategic research tool to help make effective use of this information, particularly for the mouse, the standard animal for studying mammalian development. To this end, we propose to build a three-dimensional, computer- based model of the mouse embryo. The model will cover successive stages of development and will be labelled with the major tissues and organs, thus forming a 'digital atlas'. In parallel with the work proposed here, our collaborators will use this atlas as the platform for a database that brings together information on gene expression, cell lineage, and anatomy within a common framework. We propose to make the atlas using high-resolution digital reconstructions of serially-sectioned mouse embryos (days 1-14 p.c., covering Theiler stages 1-22) and 'painting' all the major tissues onto the reconstruction. For this, we will use the tissue reconstruction technology developed in the MRC Human Genetics Unit (Western General Hospital, Edinburgh). Our specific contribution will be to convert the reconstructed images into a biologically meaningful atlas by annotating the structures and creating a database of developmental tissue relationships. To make a computer- based digital atlas of mouse development (days 1-14, stages 1-22) in which the major tissues and organs are delineated and named. The atlas will be in CD-ROM format and will be accompanied by a database containing information on tissue type, tissue derivation and cell lineage.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Molecular Biology (SCM) [1986]
Funding Scheme	X – not Funded via a specific Funding Scheme

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