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The architecture of a biosynthetic machine: structural studies on the pentafunctional AROM protein and its domains

Reference	SBD07628
Principal Investigator / Supervisor	Professor John Coggins
Co-Investigators / Co-Supervisors	Professor Neil William Isaacs, Dr Adrian Lapthorn
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	144,522
Status	Completed
Type	Research Grant
Start date	01/06/1997
End date	30/11/2000
Duration	42 months

Abstract

The overall aim of this project is to determine the 3d structure of the pentafunctional AROM protein which catalyses steps 2 to 6 of the shikimate pathway in fungi. The first stage will be to complete the structural analysis of the five monofunctional enzymes corresponding to the five AROM protein domains. Specifically this will require determining the 3d structures of shikimate kinase and shikimate dehydrogenase. Subsequently the AROM protein itself and the bifunctional plant dehydroquinase-shikimate dehydrogenase will be studied.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Structural biology and design applications (SBD) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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