BBSRC Portfolio Analyser
Award details
High-resolution structures of extracellular respiratory proteins by electron cryomicroscopy and angular reconstitution
Reference
SBD07611
Principal Investigator / Supervisor
Professor Marin Van Heel
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
175,560
Status
Completed
Type
Research Grant
Start date
05/06/1997
End date
05/06/2000
Duration
36 months
Abstract
We seek to determine the structures of large extracellular respiratory proteins, including the keyhole limpet (Megathura crenulata) haemocyanin (KLH: a strong immunostimulant) and the haemoglobin of Lumbricus terrestris, to resolutions better than - 10 angstron using cryomicroscopy and angular reconstitution. The reconstructions will be interpreted by fitting known X-ray structures of domains and/or subunits of related proteins. In addition to elucidating the structures and possibly the structure-function relations of these intriguing, allosteric proteins, we also want to establish the single-particle methodology as a fast and reproducible way to visualise alpha -helics within large oligomeric proteins.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Structural biology and design applications (SBD) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search