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Structure and catalytic function of flavodin reductase-flavodoxin linked sulphur insertion enzymes
Reference
SBD07593
Principal Investigator / Supervisor
Professor Robert Baxter
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
139,990
Status
Completed
Type
Research Grant
Start date
18/03/1997
End date
18/03/2000
Duration
36 months
Abstract
The mechanistic processes of carbon-sulphur bond formation in nature are in general poorly understood reactions which lack chemical analogy The SAM-mediated introduction of the sulphur atom of the biotin skeleton requires the specific bioB protein, flavodoxin, flavodin reductase and at least one other protein. This proposal seeks to clarify the interactions between flavodoxin, its reductase and pbioB in the synthase complex; and to determine the sequence of events leading to C-S bond formation. This work is relevant to the action of related enzymes of thiamine and lipoate synthesis and may have importance in biotechnological applications.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Structural biology and design applications (SBD) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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