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Ab initio phasing of macromolecular crystal structures

Reference	SBD07592
Principal Investigator / Supervisor	Dr Peter Main
Co-Investigators / Co-Supervisors	Professor George Dodson
Institution	University of York
Department	Physics
Funding type	Research
Value (£)	116,457
Status	Completed
Type	Research Grant
Start date	01/05/1997
End date	01/05/2000
Duration	36 months

Abstract

We have developed a method of obtaining low resolution phases directly from the X- ray data of a single crystal. We propose to investigate methods to extend these phases to a resolution at which existing density modification techniques can be used, thus providing a complete ab initio determination for macromolecular crystal structures. We describe two new approaches. The first involves the wavelet transform, a method of encoding information with an enormous range of practical applications. A second approach will base phase extension studies on a generalisation of the well-known Patterson function. The double Patterson contains phase information and its power has already been demonstrated.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Structural biology and design applications (SBD) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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