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Molecular organisation of rDNA transcription complexes
Reference
SBD07535
Principal Investigator / Supervisor
Professor Peter Shaw
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
Cell and Develop Biology
Funding type
Research
Value (£)
154,251
Status
Completed
Type
Research Grant
Start date
01/11/1997
End date
01/11/2000
Duration
36 months
Abstract
We shall determine the ultrastructural organisation of active RNA polymerase I transcription complexes by a combination of different microscopies (confocal, TEM, tilted view reconstruction, TEM of replicas). We will determine their structures, both in their native conformation in well-preserved (rapidly-frozen) cells and at differing degrees of disruption by hypertonic and physical spreading, in order to arrive at a detailed picture of the native, active conformation.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Structural biology and design applications (SBD) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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