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Analysis of hinge rotations in the GroEL ATPase cycle
Reference
SBD07529
Principal Investigator / Supervisor
Professor Helen Saibil
Co-Investigators /
Co-Supervisors
Professor Janet Thornton
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
45,014
Status
Completed
Type
Research Grant
Start date
16/03/1997
End date
16/03/1998
Duration
12 months
Abstract
We aim to determine the allosteric mechanism of nucleotide-induced conformational changes in chaperonins and to analyse the inter-domain hinge rotations in GroEL induced by nucleotide and GroES binding. Combining information from atomic structures and from a large number of cryo electron microscopy (EM) structures enables us to examine the mechanism of domain rotations. This has important implications for chaperonin assisted protein folding, and in general for allosteric systems. Moreover, protein misfolding and aggregation play a key role in prion and other amyloid diseases.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Structural biology and design applications (SBD) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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