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Structure/function analysis of three proteins required for the response to DNA damage
Reference
SBD07487
Principal Investigator / Supervisor
Dr Felicity Zoe Watts
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Sch of Life Sciences
Funding type
Research
Value (£)
43,754
Status
Completed
Type
Research Grant
Start date
01/12/1997
End date
01/05/1999
Duration
17 months
Abstract
The aims of this project are to obtain information on the structure/function relationships in three highly conserved eukaryotic proteins, Rad31, Rhp9 and Rad32, which are required for the response to DNA damage, and to produce exploitable protein variants. Specifically, investigation will be geared towards use of these proteins, or variants, (a) as potential targets or tools for anti-cancer therapy and (b) to increase homologous recombination frequencies for application to biotechnology- related processes. We will (1) carry out mutagenesis on the yeast sequences and assay mutations in S. pombe, (2) carry out crystallisation trials on the yeast proteins and (3) analyse the effect of selected mutations in human cDNAs in mammalian cells.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Structural biology and design applications (SBD) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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