BBSRC Portfolio Analyser
Award details
The hammerhead ribozyme: RNA folding and catalytic activity
Reference
SBD07464
Principal Investigator / Supervisor
Professor David Lilley
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
136,364
Status
Completed
Type
Research Grant
Start date
01/03/1997
End date
01/03/2001
Duration
48 months
Abstract
RNA catalysis is of both fundamental and practical importance. The hammerhead ribozyme undergoes a self-cleavage reaction at a defined site within a conserved core sequence, in the presence of certain divalent metal ions, giving potential as an antiviral therapeutic agent. We have shown that the hammerhead undergoes a well- defined folding process in response to the addition of ions. It is the purpose of the present investigation to extend our understanding of this folding process in the light of two crystal structures, and the relationship to the generation of catalytic activity. The hammerhead provides a well-defined system for the study of RNA folding, which is central to most biological processes that involve RNA species.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Structural biology and design applications (SBD) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search