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Retroviral engineering: structural studies of retroviral matrix proteins
Reference
SBD07462
Principal Investigator / Supervisor
Professor Steve Matthews
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
142,666
Status
Completed
Type
Research Grant
Start date
01/07/1997
End date
31/07/2001
Duration
49 months
Abstract
Retroviral matrix proteins (MAs) have key roles in viral assembly, envelope incorporation and nuclear import. In order to aid rational vector engineering, a greater structural understanding of these proteins is required. We propose to advance our understanding towards a complete picture of MA design. We will determine the solution structures of type D and spumavirus MAs by nuclear magnetic resonance (NMR). We will also examine the structural role of the myristoyl group in retroviral MAs. This structural information, in combination with NMR binding studies, will provide the necessary tests for the current hypothetical models for retroviral MA targeting, organisation and envelope incorporation.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Structural biology and design applications (SBD) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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