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Tests of the free-radical damage theory of ageing in a mammal
Reference
SAG10032
Principal Investigator / Supervisor
Professor John Speakman
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
Inst of Biological and Environmental Sci
Funding type
Research
Value (£)
195,660
Status
Completed
Type
Research Grant
Start date
15/02/1999
End date
15/02/2002
Duration
36 months
Abstract
This project involves four tests of the free-radical damage theory in a small mammal model; the short-tailed field vole (Microtus agrestis). This model is useful because these animals live for a maximum 18-24 months in captivity. The first two experiments involve experimentally increasing (and measuring) the energy expenditure of the animals using manipulations of ambient temperature and exercise, and examining the impacts on lifespan, oxidative damage to DNA, protein and lipids and levels of free-radical scavenging enzymes - superoxide dismutase, catalase antioxidants (vitamins C and E). In all the experiments I will use matched sibling pairs to minimise any effects of genetic variation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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