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Integrative models of cellular ageing
Reference
SAG10015
Principal Investigator / Supervisor
Professor Tom Kirkwood
Co-Investigators /
Co-Supervisors
Institution
Newcastle University
Department
Inst of Health and Society
Funding type
Research
Value (£)
121,331
Status
Completed
Type
Research Grant
Start date
01/12/1998
End date
30/11/2002
Duration
48 months
Abstract
Multiple molecular and cellular mechanisms contribute to ageing. Understanding how these mechanisms interact is an essential aspect of research into the integrative biology of ageing. We have developed a network model demonstrating important synergism and interaction between three major mechanisms of cellular ageing (accumulation of defective mitochondria, oxidative damage by free radicals, accumulation of aberrant proteins). We now aim to include genome instability (mutations, telomere loss) and to allow for effects of cell renewal and turnover (important in many body tissues). An interactive web site will be constructed so other groups can run simulations of the models to both maximise their utility and to aid further development.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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