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Prohormone activation by the brain enriched cytochrome P450 Cyp7b: relationship with ageing and cognitive function
Reference
SAG10011
Principal Investigator / Supervisor
Dr Joyce Yau
Co-Investigators /
Co-Supervisors
Professor Richard Lathe
,
Professor Jonathan Seckl
Institution
University of Edinburgh
Department
Centre for Reproductive Biology
Funding type
Research
Value (£)
152,137
Status
Completed
Type
Research Grant
Start date
15/02/1999
End date
15/02/2002
Duration
36 months
Abstract
Circulating dehydroepiandrosterone (DHEA) levels fall dramatically with ageing, DHEA improves memory in rodents and perceived well-being in middle-aged humans but, although it has been suggested to antagonise the deleterious effects of glucocorticoids, its mechanism of action is obscure. We have recently cloned and characterised a novel cytochrome P450, Cyp7b, predominantly expressed in brain, which converts DHEA to 7 alpha-hydroxyDHEA (7HD), an active metabolite that directly antagonises the glucocorticoid response. We propose to determine 1) the relationship between Cyp7b substrates and products (tissue and circulating levels), and Cyp7b expression with cognition and ageing and 2) the central effects of 7HD and related Cyp7b products in ageing rodents.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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