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Investigation of the molecular basis of replicative senescence: regulation of p21 and its role in imposing a replication block
Reference
SAG10001
Principal Investigator / Supervisor
Professor Lynne Cox
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
215,288
Status
Completed
Type
Research Grant
Start date
09/11/1998
End date
01/01/2002
Duration
38 months
Abstract
Progression towards cellular senescence is associated with a marked accumulation of a senescent cell derived inhibitor of DNA replication called p21Sdi1. In the proposed project, transcriptional induction and protein stabilisation will be analysed as possible mechanisms to account for age-related increases in p21 protein levels. In particular, pathways affecting the proteosomal degradation of p21 in induction of cellular senescence. Finally, the impact of p21 on replication during cellular ageing in vitro will be studied, particularly focusing on pathway of Okazaki fragment processing, and examining possible involvement of the RecQ helicase implicated in the progeroid Werner's syndrome.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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