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Mechanisms of extended lifespan in C. elegans age mutants

Reference	SAG09988
Principal Investigator / Supervisor	Dr Gordon. Lithgow
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	168,122
Status	Completed
Type	Research Grant
Start date	14/12/1998
End date	14/12/2001
Duration	36 months

Abstract

We aim to describe normal ageing processes in the nematode Caenorhabditis elegans and in particular the relationship between ageing and stress response genes. We have previously demonstrated that disruption of the insulin-like signalling pathway, which extends lifespan, also confers thermotolerance and elevated heat shock protein (hsp) synthesis. We propose a detailed investigation into the regulation of hsp genes by this pathway in a series of mutant strains which exhibit extended lifespan. Consequently, we shall determine the specific regulatory alterations associated with slowed ageing. This will be complemented be studies on the effects of pharmacological manipulation of the insulin-signalling pathway on ageing. We also propose a direct test of the influence of molecular chaperone proteins on normal ageing rates by the construction of transgenic strains which over-express inducable hsp genes.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Initiative on Science of Ageing (SAG) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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