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Biological determinants of ageing: insulin/IGF signalling dietary restriction and reproduction in Drosophila melanogaster and Caenorhabditis elegans

Reference	SAG09982
Principal Investigator / Supervisor	Professor David Gems
Co-Investigators / Co-Supervisors	Dr Sally Leevers, Professor Linda Partridge
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	204,455
Status	Completed
Type	Research Grant
Start date	17/09/1998
End date	17/11/2001
Duration	38 months

Abstract

Recently, lifespan-extending mutants in C. elegans have been shown to be defective in the insulin/IGF signalling pathway. Dietary restriction (DR) increases lifespan in many species, including mammals. We propose an integrated study of ageing in D. melanogaster and C. elegans. Newly available insulin/IGF signalling pathway mutants will allow us to establish if the pathway regulates lifespan in Drosophila. The role of the pathway, and of reproduction, in mediating the effects of DR on lifespan will be examined. We shall establish if lifespan-extension by mutants, DR and cessation of reproduction is associated with resistance to thermal stress. We shall also measure full life history effects of insulin/IGF pathway mutants, to determine if lifespan-extension has a downside, through pleiotropic negative effects on pre- adult development or fertility.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Initiative on Science of Ageing (SAG) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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