Award details

Longitudinal and cross-sectional studies of normal ageing in mice: cognitive neurochemical and neural analyses

Reference	SAG09973
Principal Investigator / Supervisor	Dr Lawrence Wilkinson
Co-Investigators / Co-Supervisors	Dr Piers Emson, Professor Keith Kendrick
Institution	Babraham Institute
Department	Neurobiology Programme
Funding type	Research
Value (£)	324,808
Status	Completed
Type	Research Grant
Start date	01/11/1998
End date	01/02/2002
Duration	39 months

Abstract

The project examines the course of normal ageing in the inbred C57B/6 mouse, evaluating concurrently, the specific nature and extent of age-related deficits in cognitive functioning and the underlying neurochemical and neural changes which may contribute to this decline. Recognising the complex mixture of deficits seen in the healthy aged human population, which involve general reductions in the speed of responding as well as variable , diffuse effects on more specific aspects of cognitive functioning spanning attentional, mnemonic and executive domains, the animals will be tested in behavioural tasks that tax simple processing efficiency, visuospatial attentions, short term memory and reversal learning. Additionally, as the effects of normal ageing are insidious in onset and progress at different rates in different individuals a comparison will be made between longitudinal (where subjects are assessed repeatedly as they age) and cross-sectional (where subjects are assessed once at a set age) ageing analyses. In this way, both the progressive nature of neural and cognitive deficits associated with normal ageing as well as any protective effects of practice will be revealed.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Initiative on Science of Ageing (SAG) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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