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Ageing effects on the immunoregulation of parasite infection
Reference
SAG09972
Principal Investigator / Supervisor
Professor Richard Grencis
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
233,989
Status
Completed
Type
Research Grant
Start date
01/10/1998
End date
01/10/2001
Duration
36 months
Abstract
It is becoming well established that post-maturational ageing has a profound influence on the functioning of the acquired immune system. Most studies have concentrated upon in vitro investigation of immune responses to defined protein antigens. Few have examined in detail the consequences of ageing on the overall response to infectious agents in vivo. The present project will utilise a well-defined model of intestinal nematode infection to comprehensively define the effects of postmaturational ageing on the immunoregulatory mechanisms controlling infection in vivo and test the hypothesis that a selective defect in type 2 responses occurs with increased age which has functional consequences in terms of resistance to infection.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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