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The role of autocrine factors in the age-related differences in growth rates of human lens cells

Reference	SAG09971
Principal Investigator / Supervisor	Professor George Duncan
Co-Investigators / Co-Supervisors	Professor John Forrester, Dr R Warn
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	113,064
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	01/01/2001
Duration	27 months

Abstract

An age-related decline in growth occurs when human lens cells are grown on their natural matrix in a protein-free medium. It is proposed therefore that a breakdown in autocrine controlled growth is responsible. Furthermore, aged cells can be driven at young rates by serum. It is hypothesised therefore that it is not the receptor mechanisms that run down with age, but rather the production of autocrine factors. We shall therefore investigate the role of certain growth factor systems in these age related differences. Growth factor gene expression, protein production and distribution will be determined as a function of age. Aqueous humour will be assayed for possible exogenous factors. Finally we will investigate at different ages the effects of parcrine addition and functional inhibition of growth factor/receptor systems on cell growth and autocrine production.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Initiative on Science of Ageing (SAG) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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