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Ageing-related muscle dysfunction: A failure of adaptation to oxidative stress?
Reference
SAG09956
Principal Investigator / Supervisor
Professor Malcolm Jackson
Co-Investigators /
Co-Supervisors
Institution
University of Liverpool
Department
Medicine
Funding type
Research
Value (£)
162,665
Status
Completed
Type
Research Grant
Start date
01/11/1998
End date
01/11/2001
Duration
36 months
Abstract
The cause of skeletal muscle dysfunction with ageing are unknown. Contractile activity increases mitochondrial superoxide release which has been proposed to lead to oxidative damage to muscle cells with advancing age. Cells adapt to oxidative stress by increased expression of various proteins, but adaptive responses to other stress are attenuated in aged tissues. We will determine whether ageing attenuates the adaptive response of skeletal muscle to exercise-induced oxidative stress and the likely role of this in ageing-related muscle dysfunction. mRNA differential display techniques will be used to characterise the adaptive response of myotubes to oxidative stress in vitro. cDNA obtained from these studies will then be used as hybridisation probes to characterise and compare the adaptive responses of skeletal muscle to exercise-induced oxidative stress in aged and adult mice in vivo.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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