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CA2+ homeostasis and metabolic changes in aged neurons
Reference
SAG09930
Principal Investigator / Supervisor
Dr Emil Toescu
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Medical Sciences - Physiology
Funding type
Research
Value (£)
351,152
Status
Completed
Type
Research Grant
Start date
03/08/1999
End date
03/09/2004
Duration
61 months
Abstract
Neuronal ageing is an important 'frontier' in science and much remains to be understood about the mechanisms of physiological ageing. By use of cellular neurophysiology techniques this study will clarify the extent of changes of important neuronal metabolic parameters: Ca2+ homeostasis, mitochondrial function and free radicals production, which have been proposed to mediate cellular senescence. To date no integrative studies are available to confirm these hypotheses or to explore the possible links between them. The other strengths of this project are: a) exclusive use of the most physiological neuronal preparation (the brain slice); b) assessment of the metabolic changes as a developing process, using different age groups from adult to old ('longitudinally'); c) analysis of the region specificity of these changes ('horizontally': neocortex, hippocampus and cerebellum).
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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