BBSRC Portfolio Analyser
Award details
A strategy for cloning genes responsible for cellular senescence
Reference
SAG09921
Principal Investigator / Supervisor
Dr Ian Kill
Co-Investigators /
Co-Supervisors
Institution
Brunel University London
Department
Biological Sciences
Funding type
Research
Value (£)
100,762
Status
Completed
Type
Research Grant
Start date
01/10/1998
End date
01/04/2000
Duration
18 months
Abstract
The aim of the work is to use a cell-free extract of S-phase human cells as a bioassay to detect activities derived from senescent cells which prevent DNA replication. Senescent cell-derived inhibitory activities will be obtained initially from cytosolic extracts of senescent cells and subsequently from a pool of proteins expressed en masse from a cDNA library of senescent cell- specific mRNAs. Senescent cell extracts will be tested for ability to inhibit specific cylin-dependent kinase activities in vitro. Completion of the project will provide a reliable bioassay for selective screening of cDNA libraries to clone genes involved in cellular ageing.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search