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Molecular control of murine gammaherpesvirus-68 lytic infection by type I interferons

Reference	S20415
Principal Investigator / Supervisor	Dr Bahram Ebrahimi
Co-Investigators / Co-Supervisors
Institution	University of Liverpool
Department	Infection and Host Defence
Funding type	Research
Value (£)	174,488
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

Our work suggests that transcriptional control is a major strategy adopted by gammaherpesviruses during the lytic phase of infection, whereas, interferon-mediated control of the lytic infection appears to be post-transcriptional. We propose to define and characterise these molecular mechanisms by integrating in vitro and in vivo assay systems, bacterial artificial chromosome-based technology and DNA microarray platforms. We will identify the viral sequences associated with this phenomenon as well as providing a conceptual picture of how interferon-mediated pathways control gammaherpesvirus lytic infections. Defining these regulatory elements will also improve our current understanding of virus reactivation, which is commonly associated with clinical disease.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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