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The characterisation and functional role of novel estrogen receptors in the prosobranch mollusc Marisa cornuarietis
Reference
S20400
Principal Investigator / Supervisor
Dr Edwin Routledge
Co-Investigators /
Co-Supervisors
Professor Susan Jobling
,
Dr Mariann Rand-Weaver
Institution
Brunel University London
Department
Institute for the Environment
Funding type
Research
Value (£)
181,011
Status
Completed
Type
Research Grant
Start date
15/03/2004
End date
14/03/2007
Duration
36 months
Abstract
Exposure of Marisa cornuarietis to estrogens affects both the differentiation of its reproductive organs and its fecundity. There is, however, no proven mechanistic explanation for these effects as little is known about the role of estrogens in molluscan endocrinology. The main objective of the project is to characterise the estrogen (ER) receptor in Marisa cornuarietis and to assess its functional role by: (a) assessment of DNA and ligand binding in vitriol; (b) assessment of transcriptional activity in vitro; and (c) by measuring developmental expression of the receptor during exposure to estrogens and/or antiestrogens. The results will enhance understanding of the biological role of putative estrogen receptors in prosobranch molluscs.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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