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Adaptation of Caenorhabditis elegans technology to identification and expression of parasite target genes
Reference
S20387
Principal Investigator / Supervisor
Dr Collette Britton
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Wellcome Ctre for Molecular Parasitology
Funding type
Research
Value (£)
181,263
Status
Completed
Type
Research Grant
Start date
01/01/2004
End date
31/03/2007
Duration
39 months
Abstract
Identification of novel target antigens and expression of these in a suitable form are crucial aspects of current parasite vaccine development. To exploit the genome sequence information available for many parasitic nematodes, we aim to develop and optimise dsRNA interference (RNAi) technology as a functional genomic approach and for large scale screening to identify novel targets of control. We will also examine the suitability of C. elegans as a heterologous system for expression of nematode vaccine candidates in a form similar to the native protein, by comparing the biochemistry, activity and immunogenicity of C. elegans expressed antigens relative to native antigens.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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