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Role of c-Jun in axonal regeneration
Reference
S20299
Principal Investigator / Supervisor
Professor Gennadij Raivich
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Maternal & Fetal Medicine
Funding type
Research
Value (£)
243,723
Status
Completed
Type
Research Grant
Start date
12/01/2004
End date
11/01/2007
Duration
36 months
Abstract
The aim of the proposed study is to explore the function of c-jun in the regenerating nervous system. The rapid upregulation and phosphorylation of the AP-1 transcription factor c-Jun in injured neurons suggests that this protein could serve as a master switch controlling the regeneration and cell death programs of gene expression. The proposed project will explore this hypothesis by examining the role of c-jun in axonal regeneration, neuronal cell death, survival and functional repair following neural injury using transgenic mouse mutants with c-jun mutations. Here discrete mutations in the molecule could improve repair, leading to new pharmacological strategies for CNS injury.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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