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The bone morphogenic protein system: a novel local system controlling follicle selection in monovular species
Reference
S20230
Principal Investigator / Supervisor
Professor Bruce Campbell
Co-Investigators /
Co-Supervisors
Dr Peter Marsters
Institution
University of Nottingham
Department
Div of Midwifery
Funding type
Research
Value (£)
272,918
Status
Completed
Type
Research Grant
Start date
01/11/2003
End date
31/03/2007
Duration
41 months
Abstract
The FecB gene in sheep, which increases prolificacy through precocious follicle and oocyte maturation, has recently been identified as a mutation of the BMP-1B receptor. Although studied in rodents, the role of the BMP system in regulating ovarian function in monovulatory species is poorly understood. Using novel culture and whole animal models and advanced molecular techniques, we aim to study the role of BMPs in regulating gonadotrophin-stimulated follicular differentiation and to elucidate the consequences of the FecB mutation on downstream signalling pathways and induction of cellular differentiation by different BMP receptor ligands. This information could lead to the development of revolutionary new strategies for ovarian stimulation.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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