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An integrated proteomic and genetic approach to identify a novel axonal growth factor from developing Xenopus limbs

Reference	S20148
Principal Investigator / Supervisor	Dr john pizzey
Co-Investigators / Co-Supervisors	Professor Michael Dunn, Dr David Alan Tonge
Institution	King's College London
Department	Institute of Psychiatry
Funding type	Research
Value (£)	139,973
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2006
Duration	24 months

Abstract

The mechanisms for the innervation of vertebrate limbs are unknown but are known to involve a panel of factors, some of which are essential for directing axons to their correct targets, while others are necessary to exclude axons from inappropriate domains. As a result of our earlier studies of axolotl blastemae, we have now identified apparently novel neurotrophic activity within the limbs and tails of Xenopus tadpoles. We have established that the activity is associated with migrating epidermal cells from these structures and have initiated proteomic and molecular biological strategies to elucidate the molecular basis of this activity. By a combination of 2-D gel electrophoresis and analysis of a subtractive library we have already constructed, we are now in a position to determine the molecular identity of the factor(s) responsible.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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