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Trophoblast invasion is regulated by decidua derived cytokine production
Reference
S19967
Principal Investigator / Supervisor
Professor Stephen Robson
Co-Investigators /
Co-Supervisors
Dr Judith Bulmer
,
Dr Gendie Lash
,
Dr Roger Searle
Institution
Newcastle University
Department
Newcastle University Department
Funding type
Research
Value (£)
332,586
Status
Completed
Type
Research Grant
Start date
01/12/2003
End date
30/11/2006
Duration
36 months
Abstract
Invasion of uterine decidua by interstitial trophoblast during the first half of pregnancy, with subsequent remodelling of spiral arteries, is necessary for successful placentation. The factors regulating trophoblast invasion are poorly understood but decidual cytokines may influence trophoblast behaviour in a paracrine or autocrine fashion. The proposed project will utilise humanplacental bed tissues and in vitro models to test the hypothesis that interferon gamma, tumour necrosis factor alpha and transforming growth factor beta 1, secreted by uterine killer cells in response to HLA-G-expressing trophoblast, temporally and/or spatially regulate trophoblast invasion by inducing apoptosis and/or altering protease production.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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