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Functional analysis of cannabinoid signalling in a post-genomic model invertebrate
Reference
S19916
Principal Investigator / Supervisor
Professor Maurice Elphick
Co-Investigators /
Co-Supervisors
Institution
Queen Mary University of London
Department
Sch of Biological and Chemical Sciences
Funding type
Research
Value (£)
248,483
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
The cannabinoid signalling system is an important regulator of physiological processes in mammals ¿ e.g. retrograde synaptic communication in the brain. Phylogenetic analysis indicates that cannabinoid receptors are absent in protostomian invertebrate model species such as Drosophila and C. elegans and probably originated in a deuterostomian invertebrate (Elphick and Egertova, 2001). Importantly, the first invertebrate cannabinoid receptor gene to be identified (CiCBR) was recently discovered in the urochordate Ciona intestinalis (Elphick et al., 2003). The aim of this project will be to exploit Ciona as a new post-genomic model simple system for molecular, physiological, behavioural and developmental analysis of cannabinoid signalling.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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