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Characterisation of the role of metabotropic glutamate receptors in persistent inflammatory pain and hyperalgesia
Reference
S19801
Principal Investigator / Supervisor
Professor Andrea Nolan
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary Cell Sciences
Funding type
Research
Value (£)
294,295
Status
Completed
Type
Research Grant
Start date
29/03/2004
End date
28/06/2007
Duration
39 months
Abstract
Cellular mechanisms of inflammatory pain and hyperalgesia are intimately linked with neuronal plasticity in spinal cord and consequently with altered gene expression. We have demonstrated that metabotropic glutamate group I and II receptors are differentially regulated in persistent inflammation in sheep. We hypothesise that the group I and II spinal mGluRs are involved in different phases of the inflammatory pain process, in particular the maintenance and resolution phases, respectively. We propose to test this hypothesis using sheep with characterised persistent inflammatory pain and hyperalgesia. Furthermore, we propose to identify the roles of spinal and peripheral group III mGluRs in this model.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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