Award details

Integration of the innate immune system with mammalian reproduction

ReferenceS19795
Principal Investigator / Supervisor Professor Iain Sheldon
Co-Investigators /
Co-Supervisors
Professor Clare Bryant
Institution Royal Veterinary College
DepartmentClinical Sciences and Services
Funding typeResearch
Value (£) 192,362
StatusCompleted
TypeResearch Grant
Start date 03/02/2004
End date 02/02/2007
Duration36 months

Abstract

Uterine bacterial infection causes abnormal ovarian hormone patterns and infertility. The immune response to bacterial infection appears to interact with the reproductive system to disrupt the function of the uterus and ovary. Bacteria and their products such as lipopolysaccharide (LPS) act, at least in part, through Toll-like receptors (TLRs) in mammals. This study will test the hypothesis that the reproductive function of the ovary and uterus is perturbed by bacteria acting through TLRs. The effect of bacteria and LPS on the endocrine and immune function of the uterus and ovary will be examined using tissue culture. Molecular sciences will be used to localise TLR expression in reproductive tissues, and identify signalling pathways for inter-communication between the innate immune and endocrine systems that impact the reproductive function of mammals.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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