BBSRC Portfolio Analyser
Award details
Integration of the innate immune system with mammalian reproduction
Reference
S19795
Principal Investigator / Supervisor
Professor Iain Sheldon
Co-Investigators /
Co-Supervisors
Professor Clare Bryant
Institution
Royal Veterinary College
Department
Clinical Sciences and Services
Funding type
Research
Value (£)
192,362
Status
Completed
Type
Research Grant
Start date
03/02/2004
End date
02/02/2007
Duration
36 months
Abstract
Uterine bacterial infection causes abnormal ovarian hormone patterns and infertility. The immune response to bacterial infection appears to interact with the reproductive system to disrupt the function of the uterus and ovary. Bacteria and their products such as lipopolysaccharide (LPS) act, at least in part, through Toll-like receptors (TLRs) in mammals. This study will test the hypothesis that the reproductive function of the ovary and uterus is perturbed by bacteria acting through TLRs. The effect of bacteria and LPS on the endocrine and immune function of the uterus and ovary will be examined using tissue culture. Molecular sciences will be used to localise TLR expression in reproductive tissues, and identify signalling pathways for inter-communication between the innate immune and endocrine systems that impact the reproductive function of mammals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search