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Viral RNA transcription and replication as determinants of virulence and host specificity in morbilliviruses
Reference
S19571
Principal Investigator / Supervisor
Dr Michael Baron
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Microbiology Pirbright
Funding type
Research
Value (£)
164,632
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
31/12/2009
Duration
67 months
Abstract
Rinderpest virus is a morbillivirus, closely related to human measles virus. It shows wide variation in virulence as well as strong species specificity for causing disease. This project will use direct, cell-free measurement of viral mRNA transcription and replicative RNA synthesis from viral genomes and model genomes to determine the contribution of viral RNA synthesis to viral virulence, the specific effects of variation in viral protein and promoter sequences on viral RNA synthesis, the contribution of intracellular proteins to host specificity and tissue tropism as reflected in their effects on viral transcription and genome replication, and the roles of the viral non-structural proteins in viral RNA transcription and replication.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Animal Health, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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