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Comparative integrative physiology of novel branches of the Na+/H+ exchanger family

Reference	S19561
Principal Investigator / Supervisor	Professor Julian Dow
Co-Investigators / Co-Supervisors	Professor Shireen Davies
Institution	University of Glasgow
Department	Molecular Genetics
Funding type	Research
Value (£)	310,020
Status	Completed
Type	Research Grant
Start date	31/05/2003
End date	30/10/2006
Duration	41 months

Abstract

Na+/H+ exchangers (NHEs) are major targets both for biomedical investigation, and for novel insect control strategies. Our group was the first to characterise insect NHEs. This has opened two exciting new areas of research: i) one of the first three Drosophila genes sits in a clade with a novel human NHE, revealed by the genome project, and a new mouse EST. ii) A second Drosophila gene sits only with invertebrate members of the NHE family, and so may well be the elusive insect epithelial exchange that has been predicted to work in combination with an apical epithelial V- ATPase. Drosophila is an ideal organism for a reverse genetic approach, and our previous work has generated a unique collection of reagents. Successful completion of the work can be expected to have significance in two very different fields of research.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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