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Integrative biology of mosquito-parasite interactions by RNAi-mediated reverse genetics in Anopheles
Reference
S19551
Principal Investigator / Supervisor
Professor Andrea Crisanti
Co-Investigators /
Co-Supervisors
Professor Oliver Billker
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
306,184
Status
Completed
Type
Research Grant
Start date
01/05/2003
End date
01/05/2006
Duration
36 months
Abstract
Mosquitoes transmit major pathogens that cause malaria, filarial diseases and viral infections both in man and in animals. Following the development of an efficient gene transfer technology in Anopheles stephensi, and the recent completion of the A. gambiae genome project, we now propose to develop genomic RNA interference for functional genomic analysis in these important disease vectors. We will apply RNA interference in A. stephensi to address basic biological questions of host- pathogen interactions during the transmission of malaria parasites. In particular, we will study mosquito molecules and metabolic pathways involved in the initial differentiation of malaria parasites in the mosquito midgut and in the invasion of the salivary glands.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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