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The role of CNS purinorecptors in the control of respiration: focus on the dorsal medulla

Reference	S19519
Principal Investigator / Supervisor	Professor Kenneth Spyer
Co-Investigators / Co-Supervisors	Professor Nicholas Dale, Dr Alexander Gourine
Institution	University College London
Department	Physiology
Funding type	Research
Value (£)	346,556
Status	Completed
Type	Research Grant
Start date	01/05/2003
End date	01/05/2006
Duration	36 months

Abstract

The study will test primary hypothesis that P2X receptors in the nucleus tractus solitarii (NTS) mediate neurotransmission in the carotid chemoreceptor reflex and pulmonary stretch receptor reflex pathways. The effect of the P2X receptor blockade in the NTS on the respiratory responses to hypoxia and lung inflation will be determined. In in vivo electrophysiological studies agonists and antagonists of P2X receptors will be used to determine the role of these receptors in mediating the responses of NTS relay neurones to carotid chemoreceptor stimulation and pulmonary stretch receptor activation. Using immunocytochemistry, the classes of P2X receptors localised on these neurones will be determined, and with the use of amperometric enzymatic sensor changes in ATP and adenosine concentrations in the NTS in conditions that affect ventilatory activity will be determined.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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