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Elucidation of mechanisms underlying fluid transport across the blood-brain barrier
Reference
S19517
Principal Investigator / Supervisor
Dr Stephen Hladky
Co-Investigators /
Co-Supervisors
Dr Margery Ann Barrand
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
273,116
Status
Completed
Type
Research Grant
Start date
01/11/2003
End date
31/01/2007
Duration
39 months
Abstract
The mechanisms involved in fluid secretion into the brain both normally and during oedema formation are poorly understood but involve many different ion transporters. We intend to use methods for determining the molecular identities and activities of these transporters in primary rat brain endothelial cells, relating expression to that seen in vivo and observing how expression and activities change in cells cultured together with astrocytes or neural precursor (stem) cells. From the data generated we will construct a mathematical model that explains how these transporters secrete brain interstitial fluid and can provide predictions about changes in secretion and cell composition when the transporters are inhibited or activated.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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