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The role of Drosophila acer peptidase in reproduction heart function and circadian behaviour

Reference	S19378
Principal Investigator / Supervisor	Dr Alan Shirras
Co-Investigators / Co-Supervisors	Professor Elwyn Isaac
Institution	Lancaster University
Department	Biological Sciences
Funding type	Research
Value (£)	239,776
Status	Completed
Type	Research Grant
Start date	26/11/2003
End date	25/11/2006
Duration	36 months

Abstract

The sequencing of animal genomes has revealed an unexpectedly large M2 peptidase family, which includes mammalian angiotensin-converting enzyme (ACE). We aim to improve our understanding of the physiological roles of M2 peptidases by focusing on Drosophila Acer, an ACE-like peptidase with a highly restricted expression pattern and an unusual substrate specificity. A multidisciplinary approach will be taken, integrating genetics, molecular biology, biochemistry, physiology and behavioural studies to elucidate the function of a peptidase implicated in control of male and female reproduction as well as heart physiology and circadian behaviour.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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