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The role of gene expression in cortical plasticity

Reference	S19371
Principal Investigator / Supervisor	Professor Kevin Fox
Co-Investigators / Co-Supervisors	Professor Peter Kille
Institution	Cardiff University
Department	School of Biosciences
Funding type	Research
Value (£)	255,056
Status	Completed
Type	Research Grant
Start date	11/04/2003
End date	11/04/2006
Duration	36 months

Abstract

Our aim is to understand the molecular mechanisms underlying experience-dependent plasticity in the cerebral cortex. This involves understanding the patterns of gene expression induced by altered sensory experience. We will capitalise on the advantages of the mouse barrel cortex, mouse transgenics and gene array technology to test three specific hypotheses: 1. that CRE- mediated gene expression induced by whisker deprivation is activated by the ras/raf/MEK pathway, 2. that CREB and CRE- mediated gene expression are necessary for experience-dependent plasticity and 3. that genes involved in synapse formation/neuritis growth and regulation of the CRE activation pathway are induced by sensory deprivation. This work will allow us to understand the molecular mechanisms underlying memory, development of neuronal circuits and responses to deprivation and injury.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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