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Neural basis of a corollary discharge mechanism controlling auditory processing
Reference
S19133
Principal Investigator / Supervisor
Professor Berthold Hedwig
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Zoology
Funding type
Research
Value (£)
60,112
Status
Completed
Type
Research Grant
Start date
01/04/2004
End date
31/03/2007
Duration
36 months
Abstract
The differential processing of self-generated and external sensory information is a fundamental problem in all sensory pathways. During singing in crickets a corollary discharge presynaptically inhibits the terminals of auditory afferents and postsynaptically the thoracic interneurones. This reduces the response to self- generated sound patterns and serves to maintain the sensitivity of the crickets auditory pathway. The corollary discharge originates from the singing motor network. We will use intracellular recording and staining to identify the neuron mediating the corollary discharge and we will meticulously analyse the impact of the corollary discharge on auditory processing in double recording experiments by driving the corollary discharge neurone while recording the auditory neurons. The experiments will elucidate a basic principle of sensory processing.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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