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Genomic imprinting brain development and behaviour
Reference
S19124
Principal Investigator / Supervisor
Professor Eric Keverne
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Zoology
Funding type
Research
Value (£)
263,608
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
Targetted mutagenesis of imprinted genes produces complex phenotypes that relate to pre- and post natal growth, brain development and behaviour. We have characterised in detail, the phenotype of one such imprinted gene (Peg3) and many aspects of this phenotype (behaviour and physiology) relate to key evolutionary mammalian traits (parental conflict and genomic conflict). This study will determine the extent to which multiple aspects of this phenotype can be explained by Peg3 action on regulating the development of the hypothalamus, and basal forebrain structures (amydala, MPOA and BNST) that are important for enabling sexually dimorphic behaviour. Functional mapping of the basal forebrain nuclear areas will be assessed developmentally.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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