BBSRC Portfolio Analyser
Award details
Implication of mosquito peptidoglycan recognition proteins in immune regulation and anti-malarial defence
Reference
S18950
Principal Investigator / Supervisor
Professor Andrea Crisanti
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
263,432
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
Malaria infection of the mosquito results in the activation of an immune response that contribute to the killing of Plasmodia. Recognition of non-self leading to the activation of the known immune signalling pathways in the fruit fly have recently been shown to be mediated by members of a peptidoglycan recognition protein family that appears to represent the major pattern recognition receptors of its immune surveillance system. The role of the mosquito PGRPs in regulating its immune system and activating anti-malarial defence mechanisms will be examined through the combination of reverse genetic and comparative transcriptomic approaches. The proposed project will contribute to our understanding of mosquito immune responses to Plasmodium.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search