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Are galaninergic systems involved in sexually differentiated aspects of reproductive neuroendocrinology in the ewe
Reference
S18947
Principal Investigator / Supervisor
Professor Neil Evans
Co-Investigators /
Co-Supervisors
Dr Jane Robinson
Institution
University of Glasgow
Department
Veterinary Cell Sciences
Funding type
Research
Value (£)
321,628
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
Based upon the extensive genomic information available in rodents, a genome hopping approach will be used to characterise galaninergic systems in sheep that impact upon reproductive function (Galanin, galanin-like peptide and Galanin receptors 1-3). In situ hybridisation and real time rt-PCR will then be used to quantify expression of target genes in the ovine hypothalamo- pituitary gland complex, to address the hypothesis that inutero steroid exposure sexually differentiates galaninergic systems that impact upon the GnRH neurosecretory system and are in themselves regulated by steroids, thus inducing sex specific differences in steroid sensitive aspects of GnRH secretion e.g. the timing of puberty and oestradiol positive feedback in the ewe.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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